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Aged mice in the study showed signs of endothelial dysfunction, increased vascular stiffness, and impaired coronary microcirculation, which are hallmarks of HFpEF [17]

By extending the analysis to 15 electrophilic compounds, we noticed that a subset (4/7 tested) of senolytic chloroacetamides induced ferroptosis

This cascade may possibly lead to the proliferation, survival, migration, and differentiation of endothelial cells, which are posited to be the building blocks of new blood vessels

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S16, S17)

Whereas GPx1-4 and GPx6 contain selenocysteine in the active center, GPx5, GPx7 and GPx8 contain cysteine (Cys) residues in their active sites (Fig